Logistic regression analysis showed an elevated risk of gastric adenocarcinoma for subjects with TNFSF15 −358CC genotype (OR 1.42, 95% CI, 1.10 to 2.03, P = 0.04), but not for subjects carrying TNFSF15 TC genotype (OR 1.00, 95% CI, 0.72 to 1.40, P = 0.89), compared with TNFSF15 −358TT genotype carriers. Here, TNFSF15 is linked to gastric adenocarcinoma.