A study investigating the effects of AEE-788 on EGFR and HER2 in glioblastoma cells (LN-18 and LN-229 cell lines, respectively) expressing varying co-expression levels followed by experimental radiotherapy showed HER2-overexpressing sensitivity, while demonstrating induced inhibition on previously resistant EGFR-overexpressing cells [56]. This evidence concerns the gene EGFR and glioblastoma.