INS and hydrops fetalis: The beneficial effect of ω3 fatty acid supplementation on insulin sensitivity in other rodent HF diet-induced models may have been potentiated by three factors, 1) high ratio of ω6/ω3 used in the “control” HF diets, 2) megadoses of EPA+DHA in the fish oil HF diets, and 3) reduced weight gain and food intake observed in mice consuming fish oil-containing vs. standard HF diet.