We [28] and others [25], [32] have shown that CD94/NKG2A engagement on antiviral CD8+ T cells may be associated with dampened effector activity (e.g., cytotoxicity, cytokine production), and we have also shown induction of NKG2A expression on antigen specific CD8+ T cell following influenza infection in mice [28]. The gene discussed is CD8A; the disease is influenza.