DOT1L and posterior cortical atrophy: PCa noncoding RNA 1 (PRNCR1; PCAT-8), which is located immediately adjacent to PCAT-1 and the c-MYC oncogene at the well-known PCa risk locus on chromosome 8q24 [58, 59], was identified to be upregulated in aggressive prostate tumors [54]. PRNCR1-bound DOT1-like histone H3K79 methyltransferase (DOT1L) methylated the AR at position K349, which mediated the interaction of AR with PCGEM1, thereby resulting in ligand-independent activation of AR signaling and cell proliferation [54]. PCAT-18 was recently suggested as a biomarker for metastatic PCa [60].