EZH2 and posterior cortical atrophy: In a more recent and comprehensive study, Prensner and colleagues, by analyzing the transcriptomes of 102 prostate tumors and cell lines using next generation sequencing [56], identified 121 so far nonannotated PCa-associated noncoding RNA transcripts (PCATs). PCAT-1 was upregulated in a subset of metastatic and high-grade localized prostate tumors. PCAT-1, a transcriptional target of EZH2, stimulated cell proliferation [56] and impaired homologous recombination by repressing of the BRCA2 gene [57].