Molecular studies on the differential expression of human genes under conditions of elevated IOP revealed that MMP1, MMP10, CXCL2, and PDPN were general responders and were altered in almost all the patients with glaucoma whilst STATH, FBN2, TF, OGN, IL6, IGF1, CRYAB, and ELAM1 (marker for glaucoma) had very patient specific changes in expression [61]. Here, OGN is linked to glaucoma.