For instance, in all three NSCLC cells A549, H460, and H1299, 5-demethyltangeretin mediated G2/M cell cycle arrest by upregulating p53 and p21Cip1/Waf1 and downregulating cdc2 and cyclin B1 [25]. The gene discussed is CDKN1A; the disease is non-small cell lung carcinoma.