There were no significant differences in age, BMI, and current smokers between any of heart failure groups and the control group (P > 0.05); the variables of male, hypertension, diabetes, NT-proBNP, CCR, Cr, UA, and LVEDD were significantly different among the three groups (all P < 0.01, excluded variable of male P < 0.05). The gene discussed is NPPB; the disease is Hypertension.