Frondoside A caused a concentration-dependent reduction in the viability of lung cancer cells (LNM35, A549, and NCI-H460-Luc2), melanoma cells (MDA-MB-435), breast cancer cells (MCF-7), and hepatoma cells (HepG2) over 24 h, and increased the activities of caspases-3 and -7 in LNM35 lung cancer cells (Attoub et al., 2013). This evidence concerns the gene CASP3 and lung cancer.