Other studies reported that in vitro treatment of peritoneal macrophages with cucumarioside A2-2 stimulated cell adhesion as well as their spreading reaction and motility (Aminin et al., 2011), whereas frondoside A suppressed MMP-9 enzymatic activity, secretion, and expression in MBA-MB-231 human breast cancer cells, leading to inhibition of invasion and migration of these cells (Park et al., 2012b). Here, MMP9 is linked to breast carcinoma.