FMR1 and cancer: Weghofer et al. (2012) cross-tabulated the co-occurrence of BRCA1/2 mutations and FMR1 repeat length distribution, and observed that BRCA1/2 carriers almost invariably had low numbers of CGG repeats in their FMR1 gene (<26 CGGs), compared to controls. They inferred that BRCA1/2 mutations are embryo-lethal unless rescued by low CGG repeats in the FMR1 gene, and predicted that women with low FMR1 CGG repeats should have an increased risk of BRCA1/2-associated cancers.