Transgenic lines expressing mutant human SOD1 proteins have been successfully generated in C. elegans and recapitulate the motor neuron degeneration and paralysis characteristic of ALS patients (Figure 4B) (Witan et al., 2008; Gidalevitz et al., 2009; Wang et al., 2009; Li et al., 2014). This evidence concerns the gene SOD1 and amyotrophic lateral sclerosis.