Several transgenic lines expressing human tau harboring FTD-17 mutations (htau-FTD-17) have been generated in C. elegans (Figure 4B) (see also Section “PTL-1 as a Tau Model”; Kraemer et al., 2003; Miyasaka et al., 2005; Brandt et al., 2009; Fatouros et al., 2012). The gene discussed is MAPT; the disease is frontotemporal dementia.