In the absence of iNKT cells, influenza A (PR/8 strain) infection was shown to induce the expansion of CD11b+GR-1+ MDSCs in the lungs of mice, which suppressed influenza-specific T cell and antibody responses through the activity of both arginase and NOS, resulting in higher viral titers and increased mortality (81). The gene discussed is ITGAM; the disease is infection.