Inhibition of JEV, a mosquito-transmitted flavivirus that causes encephalitis in humans, in IFN-γ-activated RAW 264.7 macrophages in vitro correlated with NO production, and IFN-γ-activated RAW 264.7 macrophage-mediated inhibition of JEV replication in murine neuroblastoma N18 cells was NO-dependent (12). The gene discussed is IFNG; the disease is encephalitis.