Zol potently induced RP2 Vγ9δ2 T cells (but not CD4+ or Vδ1+ T cells) to produce TNFα, similar to its effect on a HD PBMC (Figure 2) whereas those of RP1 an SSc patient who had received Zol but no clinical APR did not secrete TNFα in response to Zol application in vitro. The gene discussed is TNF; the disease is systemic sclerosis.