AGTR1 and congestive heart failure: In addition, L-158809 decreases the chemoreceptor responses to hypoxia in CHF rabbits, suggesting that increases in Ang II and the expression of AT1 receptor in the carotid body play a role in the augmented carotid chemoreceptor activity and chemoreflex-mediated sympathetic overactivity in CHF (Li et al., 2006).