Nevertheless, in the context of our results and previously published data (Kittappa et al., 2007; Stott et al., 2013), the observed down-regulation of Foxa1/2 in post-mortem samples from PD patients suggests that Foxa1/2 factors and their target genes may have a specific role in the SNpc and contribute to neurodegeneration in PD patients. The gene discussed is FOXA1; the disease is Parkinson disease.