SERPING1 and Sepsis: Whereas the anti-inflammatory potential of C1-Inh is well established in a great variety of disease models like sepsis (Begieneman et al., 2012; Heydenreich et al., 2012; Mejia and Davis, 2012), ischemia/reperfusion injury (Horstick et al., 1997; Lehmann et al., 2000; Heydenreich et al., 2012), and spinal cord injury (Tei et al., 2008) the present description of C1-Inh as a powerful antithrombotic compound in TBI is novel and further adds to our understanding of this multifaceted molecule.