Hairpin Py–Im polyamides 1 and 2 were designed to target the ARE (5′-GGTACANNNTGTTCT-3′ (26)) and antagonize gene expression changes driven by the androgen receptor (AR) in the prostate cancer cell line, LNCaP (Figure 1A and B) (16,27). The gene discussed is AR; the disease is Familial prostate cancer.