As indicated by Figure 4, and similarly to what reported for HBCs [3,5], all these data suggest that these “non-ductal associated” FMCs arise at the ductal-lobular junction where potential stem/progenitor cells (CK5_6+) reside to expand the normal glandular lobules and are capable to give rise to CK8_18+/CK14+/VIM + clones responsible for the heterogeneity of these FMCs supporting the idea that tumor arise from stem cells [5,14]. Here, KRT14 is linked to neoplasm.