In the present studies focal irradiation of the tumor reduced the Th2 (IL-4 and IL-5) responses through B cells and inflammation (IL-6, IL-17, GM-CSF, IL-1α) (Fig. 12 a, b, c, d), which was accentuated by 2-DG besides removing the systemic immunosuppression through depletion of Tregs. Here, IL6 is linked to neoplasm.