In line with this notion, our results clearly show that the combination of 2-DG and radiation elicits anti-tumor immune response by not only restoring the levels of CD4+ cells, but also the levels of molecules related to its signaling i.e. CD44, CD69, CD45, TCR-β, TCR-γδ and CD28(Fig. 6a and 7a,b,c,d). Here, CD28 is linked to neoplasm.