In agreement with our findings of caspase-3 activation and reduced phosphorylation of Akt, a previous study showed that the TGM2 inhibitor KCC009 decreased Akt phosphorylation and upregulated the expression of the pro-apoptotic protein Bim, resulting in enhanced cell apoptosis in cultured mouse glioblastoma cell line [34]. The gene discussed is CASP3; the disease is glioblastoma.