Considering functional importance of the gene and since there are a) very few studies explaining the role of KCNJ11 polymorphisms (rs5219 (E23K), rs1800467 (L270V), rs5215 (V337I), rs41282930 (S385C)) in South Asian population, b) no reported large scale GWAS studies and c) lack of comprehensive meta-analysis, we have performed a case–control association study with 400 T2D cases and 400 controls and a systematic review and meta-analysis to provide an assessment of the risk association between KCNJ11 polymorphism (rs5219) and T2D in South Asian population. The gene discussed is KCNJ11; the disease is type 2 diabetes mellitus.