In conclusion, the effects observed with αv kd and GLPG0187 treatment in both cell lines show that ITGAV inhibition results in a less malignant phenotype in vitro. αv integrin appears to be involved in proliferation, migration and clonogenicity through EMT induction, the maintenance of cancer stem/progenitor-like ALDHhi cells and CD24 expression. This evidence concerns the gene ITGAV and cancer.