On the opposite, the T668A mutation in the intracellular domain prevents the development of synaptic and memory deficits of FDDKI mice, a model of the AD-like Familial Danish dementia [21], which is due to mutations of BRI2/ITM2B, and inhibitor of APP processing by BACE1 [7]–[9]. This evidence concerns the gene BACE1 and Alzheimer disease.