Two genetic risk factors for late onset Alzheimer's disease are in the apolipoprotein-e (APOE; http://www.ncbi.nlm.nih.gov/gene/348) and translocase of outer mitochondrial membrane 40 (TOMM40) gene poly-T repeat loci (http://www.ncbi.nlm.nih.gov/gene/10452).1,2. Here, TOMM40 is linked to early-onset autosomal dominant Alzheimer disease.