SIRT1 and early-onset autosomal dominant Alzheimer disease: SIRT1 overexpression is also reported to prevent microglia-dependent Aβ toxicity in Alzheimer’s diseases through inhibiting NF-κB signaling by deacetylating the lysine 310 residue of the RelA/p65 subunit of NF-κB, thereby preventing its transcriptional activity [141].