Interestingly, a group of heritable connective tissue diseases which include syndromic aortic aneurisms, including Marfan syndrome, Loeys-Dietz syndrome, Shprintzen-Goldberg syndrome, all associated with vessel wall weakening, have been traced back to genetic variants in multiple components of the TGFβ signal network [62], [63]. The gene discussed is TGFB1; the disease is Shprintzen-Goldberg syndrome.