After adjusting for age, gender, smoking status, hypertension status, diuretic status, use of insulin or anti-diabetic pills, ACEI, statins, LDL-C, apo A1 and apo B, the OR was 7.01 (95% CI: 3.26 - 15.09) at baseline and 9.10 (95% CI: 3.93 - 21.09) after 6-month follow-up (Table 2). The gene discussed is INS; the disease is hypertensive disorder.