Some have been highly studied such as TP53 and its degrader HUWE1, and genes involved in protein-tyrosine kinase signals such as EPHA1 and EPHA3. We also identify the less-studied PTK2 and VAV1 genes in the same category, and suggest that they are more important in the study of cancer survivalness than currently appreciated. The gene discussed is VAV1; the disease is cancer.