AD is a neurodegenerative disorder that affects a large segment of older population and clinically is characterized by a progressive memory decline of the patient and, later, the presence of brain aggregates of a protein called amyloid-β (Aβ) and the accumulation of the hyperphosphorylated form of the tau protein, which later forms intraneuronal aggregates known as neurofibrillary tangles (NFTs) [18]. Here, MAPT is linked to Alzheimer disease.