UCP1 and ischemia: Primary cortical neurons from PPARγ-KO mice showed increased neuronal death, reduced expression of SOD1 (superoxide dismutase 1), catalase, glutathione S-transferase, and uncoupling protein-1 (UCP-1) after ischemia [32], suggesting that PPARγ is an important factor in the regulation of the antioxidant response in the brain.