In contrast, among the CVT cases detected in non-Ramadan months, 12 cases consumed OC and 18 had other risk factors for CVT such as hyper coagulopathy state due to factor V Leiden (3 cases), systemic lupus erythematosus (2 cases), complicated otitis and mastoiditis (2 cases), pregnancy (4 cases), a history of recent (within 6 months) caesarian section (4 cases), and severe dehydration, history of oral corticosteroid use and esteradiol injection after severe uterine bleeding (each in 1 case) (Table I). This evidence concerns the gene F5 and systemic lupus erythematosus.