Some rare SNPs of the PRM1 gene were reported to be associated with male infertility, for instance, the G107C point mutation has been observed in 135 case out of 281 infertile men by Imken et al 2009 in Moroccan and France and the C190A substitutions was reported to be associated with male infertility, observed in 48.2% of 220 infertile men in Spanish populations and G197T point mutation observed in 10% of 30 infertile men in US population (1, 30). This evidence concerns the gene PRM1 and male infertility.