Another prognostic indicator for HNSCC is sphingosine kinase 1 (SphK1), a lipid kinase that catalyzes the conversion of sphingosine to sphingosine-1-phosphate (S1P), a biologically active lipid that plays an important role in mammalian cell growth, survival, and migration [9]. The gene discussed is SPHK1; the disease is head and neck squamous cell carcinoma.