C3 and autoimmune polyendocrinopathy: Complement activation and placental inflammation are crucial events in obstetric APS.20 Decreased T2* time was observed in placentas from APS mice that received USPIO-anti-C3 antibodies compared with APS mice treated with USPIO alone and control mouse IgG-treated mice injected with USPIO-anti-C3 (Figure 5a).