High Ang-2/sVEGFR-2 ratio was associated with the presence of ascites (P = 0.003), high stage of ovarian cancer (P < 0.001), with the size of primary residual tumor >1 cm (P = 0.004), with recurrence of disease (P < 0.001) and also a trend to a high grade of ovarian cancer was noticed. This evidence concerns the gene ANGPT2 and neoplasm.