ANGPT2 and ovarian cancer: Further, when combining the serum levels of two angiogenic pathways by calculating Ang-2/sVEGFR-2 ratio it was found to be significantly elevated in ovarian cancer patients compared to women with normal ovaries (57% higher) or patients with benign (35% higher) ovarian tumors (P < 0.01 and P < 0.01, respectively) (Table 1, Figure 1F).