High-dose interleukin-2 (HD-IL-2) has been reported to induce an objective clinical disease regression in 15 to 17% of patients with metastatic melanoma and renal cell carcinoma, with 6% to 8% of cases experiencing a durable complete response of all metastases [22-24]. The gene discussed is IL2; the disease is hereditary clear cell renal cell carcinoma.