KRAS and colorectal carcinoma: To identify miRNAs that selectively alter the viability of CRC cells harboring mutant KRAS, we decided to perform replica parallel screens (Figure 1A) of synthetic miRNA mimics corresponding to 879 human miRNAs in isogenic HCT116 KRAS-wild-type (KRAS-WT) and KRAS-Mutant (G13D/−) cells [30].