The NDE1 gene is one of the ‘hot spots’ for CNVs at chromosome 16p13.11, of which deletions and duplications have been found to associate with a wide spectrum of developmental brain disorders including intellectual disability, epilepsy, autism, schizophrenia, and attention-deficit hyperactivity disorder (ADHD) (Hebebrand et al., 1994; Gillberg, 1998; Sharp et al., 2006; Ullmann et al., 2007; Hannes et al., 2009; Heinzen et al., 2010; Mefford et al., 2010). Here, NDE1 is linked to Intellectual disability.