In contrast, the CD34+CD38+ and CD34- compartments at diagnosis completely lacked prognostic impact, which strongly suggests that CD34+CD38+ and CD34- pLSCs are of minor clinical importance, at least in AML cases where these compartments are accompanied by CD34+CD38- pLSCs (as by definition is the case in our current CD34 positive patient group). The gene discussed is CD34; the disease is acute myeloid leukemia.