HPGDS and Stroke: In spontaneously hypertensive and stroke prone rats (SHR-SP), the expression of proteins such as glutathione S-transferase glutathione peroxidase are reportedly decreased together with brain total antioxidant capacity, while MDA is increased compared to spontaneously hypertensive rat (SHR) that are not stroke prone, indicating that increased oxidative stress may be a risk factor in the progression of stroke-related disease [52].