Although hypoinsulinemia and enhanced insulin sensitivity have been linked with life extension in GH-related mutants and in dietarily restricted animals, a few long-lived mutants have been reported as not being insulin hypersensitive (Conover & Bale, 2007; Conover et al., 2008) or as being insulin resistant (Kurosu et al., 2005; Bartke, 2006), as have rapamycin-treated mice (Fang et al., 2013). This evidence concerns the gene INS and Hypoinsulinemia.