GHR and dementia: It is tempting to suggest that either this increased metabolism or the increased energy consumption, or a combination of the two, might have adversely affected memory function in middle-aged GHR-KO;RIP::IGF-1 mice (relative to their standard GHR-KO controls) {as hypermetabolism is associated with dementia in mice (Knight et al., 2012) and (albeit controversially) in humans (Poehlman & Dvorak, 1998).