Conversely, our results are supported by experimental evidence on the effect of raloxifene on glucose homeostasis and diabetes: it has been shown that estradiol prevents pancreatic β-cell failure in diabetic rats fed a high-fat diet by suppressing fatty acid synthesis and accumulation within the β-cells through estrogen receptor signaling [17], and the same research group found similar results with raloxifene in an in vitro study [18]. Here, ESR1 is linked to diabetes mellitus.