PPARGC1A and neoplasm: In keeping with a context-dependent tumour suppressor and oncogenic role for AMPK [45], the comparatively high levels of PGC1α expression that we observed in the highly proliferative, i.e., with high Ki-67 expression, HGSC tumours could then be suggested to belong to a context of AMPK-mediated protection from proliferation-related oxidative stress.