Importantly, the enhanced expression of nuclear tumor antigen following gemcitabine treatment has been observed in human cancers [14], [35] and while the exact mechanism involved remains uncertain, it has been suggested that gemcitabine induced apoptosis promotes nuclear fragmentation [21] and such fragments may lead to the exposure of nuclear contents [23] and an increased availability of nuclear-bound tumor antigen for cross-presentation. This evidence concerns the gene LINC01194 and cancer.