KLK3 and posterior cortical atrophy: A urine PCA3 score (PCA3-to-PSA ratio) with a cut-off of ≥35 had an average sensitivity of 66% and a specificity of 76% for the prediction of PCa at biopsy (area under the curve (AUC) 0.75), while serum PSA had only a specificity of 47% [18, 42].