Targeted overexpression of MCM7 in epidermal tissue predisposed mice to form malignant tumors, as animals that overexpressed MCM7 saw a decrease in the average time to develop tumors in response to carcinogens and an increase in the frequency and propensity of these tumors to form squamous cell carcinomas relative to wild type littermates [81]. The gene discussed is MCM7; the disease is squamous cell carcinoma.