The facts that TAU is a substrate of many of the kinases operating in the pathways modulated by Aβo (Table 2) or by AD risk factors or genes (Table 1) and that TAU is phosphorylated by neurons challenged with Aβo or other stresses/conditions [95–98], provide a mechanistic explanation as to TAU hyperphosphorylation in AD [5, 23, 99, 100]. Here, ABO is linked to Alzheimer disease.