Ten enzymes (ATP5F1, SDHD, ATP5B, UQCRC1, NDUFA7, ATP6V0E1, NDUFB9, NDUFS2, NDUFB5, and CYC1) out of 135 proteins participating in this pathway were overexpressed in cancer (Table 2 and Supplementary Table S1). The gene discussed is SDHD; the disease is cancer.