GAPDH and cancer: Analysis was done in a tissue-specific manner but demonstrated similar patterns of enzymes enrichment in various cancers, for example, glycolytic enzymes, alpha enolase ENO1 (EC 4.2.1.11), pyruvate kinase, muscle PKM2 (EC 2.7.1.40), and glyceraldehyde-3-phosphate dehydrogenase GAPDH (EC 1.2.1.12), were found in three different types of cancer [16].