Ten enzymes (TPI1, PGAM1, ENO1, PKM2, ALDH3A1, GAPDH, LDHB, ALDH3B1, ALDH3B2, and ALDOA) from the glycolysis pathway (62 genes) are overexpressed in cancer (Table 2 and Supplementary Table S1). The gene discussed is ENO1; the disease is cancer.