In a meta-analysis consist of cohort studies, Dudding et al (37) reported that it seems the maternal factor V Leiden mutation is able to increase the risk of preeclampsia until fifty percent levels (50%) and Kosmas et al (38) assessed results from 19 studies that have investigated to find this correlation and identified women with this mutation are at increased risk for preeclampsia 2.5 fold higher than women without the mutation. This evidence concerns the gene F5 and preeclampsia.