In another study by Dalmaz et al (39) in Brazilian population, they considered the correlation between methylenetetrahydrofolate reductase (MTHFR), Prothrombin Mutation (FII), Plasminogen activator inhibitor (PAI-1) and also factor V Leiden mutation and mild/sever preeclampsia in 75 pregnant women. This evidence concerns the gene SERPINB2 and preeclampsia.