Although it is often believed that the p53 is important in responding to DNA damage, oncogenic motivation and hypoxia; increased ability of p53 in regulating some features of cellular metabolism in some disease development is now being revealed.26 Hence, the increased level of p53 in patients with advance liver disease underlines the importance of p53 in directing metabolic remodeling and metabolic disorders. The gene discussed is TP53; the disease is metabolic disease.