Within 5 weeks of dox treatment, shBrd4 mice displayed follicular dysplasia characterized by abnormal hair growth and subsequent alopecia (Figures 2C and S3B), whereas control mice maintained on dox, and CAG-rtTA3; TtG-Brd4 mice maintained on a normal diet (data not shown), were phenotypically normal. The gene discussed is BRD4; the disease is alopecia.